The Buckeyes have been the favorites to make it to the College Football Playoff and are the No. 2 seed in the playoff’s top four.
Clemson has been the other team in the Playoff’s top eight and is currently at No. 10.
Ohio State won the BCS title last season and is No. 3 in the BCA.
But the Buckeyes will be hoping to get the win at Clemson.
Ohio State’s defense is in its best form of the season, ranking third in the country in total defense (288.3 yards per game) and third in passing defense (219.3 ypg).
The Buckeyes are also second in total yards per play (9.2) and fifth in points per game (13.0).
Ohio State leads the nation in rushing (5.9 ypg), scoring (14.0 ppg), passing yards per attempt (5,097.0), total offense (9,715.0) and passing touchdowns (25).
Clemson is coming off a big win over Ohio State in the Orange Bowl last year, as the Tigers are No. 6 in the AP Top 25 and No. 4 in the Associated Press Coaches Poll.
Clemson’s defense has been playing at an above-average level, allowing just three touchdowns all season, including a score in the overtime game against Ohio State.
Ohio State’s offense has struggled, ranking 31st in the nation and averaging fewer than 200 yards per contest in each of the last two games.
Defensively, Clemson is No, 17 in the FBS and No, 11 in the AAC.
The last time the Buckeye defense played in the College Championship was in 2014.
Clemson beat No. 1 Alabama 21-13 in the title game.
Clemson also lost to No. 8 Alabama 21, 20 and 22-16.
Here’s the full schedule for the 2016 College Football Playoffs.
Monday, February 1: Clemson at Ohio State, 8 p.m.
ET (CBS) Tuesday, February 2: Notre Dame at Ohio St., 1 p.d.
ET Wednesday, February 3: Notre St at Ohio, 3:30 p.p.m., ESPN (CBS Sports Network) Thursday, February 4: Clemson vs. Ohio St. Saturday, February 6: Ohio St at Notre Dame, 7 p.o.m, ESPN Monday-Thursday: Ohio vs. Alabama, Clemson at Notre St., Notre Dame vs. Georgia, Ohio St vs. Miami, Clemson vs in South Carolina Friday, February 7: Ohio at Georgia, 1 p